I have found success in graduate studies by having a solid group of people supporting me. Academia can be daunting and difficult, but having friends and colleagues who are like-minded, engaged, and generally supportive has made my journey possible. Pick your department and supervisor with care, seize opportunities, explore new and old interests, maintain hobbies outside of research, and most of all: stay curious.
I would advise a prospective graduate student to do their homework before contacting prospective advisors. Check out their profile on the University website, read their most recent paper, and even reach out to a senior graduate student currently in the lab!
Be patient with yourself. As a student your job is to learn, and by necessity, fail. Solving the problem and having the right answer isn't always the same thing.
Pursue research that you truly believe has the potential to improve life. Knowing you are working toward something more than just a degree can help you find the drive to make it through the difficult or dry aspects of your time in graduate studies.
Your time in graduate studies will provide many opportunities, but don't lose touch with yourself. Take the time to do what you need to in order to maintain your sense of purpose and direction, then live out of that. Don't be afraid to try new things, but remember that no one can do everything. Be selective.
Coming from New York City, Guelph was definitely different but I would say it was a relief. It truly grounded me to not be amongst the hustle and bustle every day and it's a small town full of nice people.
My best advice for prospective grad students would be to not be afraid to put yourself out there to the individuals you want to work with or those you believe to be the best sources of information. You are your best advocate! I would suggest doing as much research as possible on different graduate programs at various institutions, as well as the research being conducted to find the best fit for yourself. In my experience, asking current grad students how their experience was and how they achieved their goals was extremely helpful as they provided their authentic opinion.