Osteosarcoma is an aggressive bone cancer in dogs and people. My lab investigates the mechanisms that permit osteosarcoma cells to spread to new sites (metastasis) and survive exposure to chemotherapy (chemoresistance). Additionally, we are working on identifying biomarkers that can help predict outcomes and/or guide therapeutic decisions for patients with osteosarcoma.
My research program seeks to understand the underlying physiology of diseases common in horses, and how these diseases can be modified with targeted nutrition, with a focus on cartilage biology.
We are interested in structure-function relationships of enzymes and enzyme evolution. We are studying steroid degrading enzymes from the pathogen Mycobacterium tuberculosis and other related bacteria. We are also interested in enzymes that can be used to detoxify environmental pollutants.
I am engaged in questions of applied landscape ecology in rural and agricultural landscapes, including changes in landscape patterns and the consequences of those changes on biodiversity, water quality, and culture.
My general research interests are interdisciplinary, and straddle the disciplines of Computer Science and Electrical Engineering. Currently, I have particular interest in developing algorithmic solutions to optimization problems that arise in both FPGA and VLSI design flows. My other active areas of research include...
