We are interested in structure-function relationships of enzymes and enzyme evolution. We are studying steroid degrading enzymes from the pathogen Mycobacterium tuberculosis and other related bacteria. We are also interested in enzymes that can be used to detoxify environmental pollutants.
Graduate students joining my team at Guelph get unrivalled opportunities to work in the lab and field answering research questions at the cutting edge of science with direct environmental and societal relevance. This important research is exciting, challenging and rewarding for the student, for me as the supervisor and for everyone else in the team.
Osteosarcoma is an aggressive bone cancer in dogs and people. My lab investigates the mechanisms that permit osteosarcoma cells to spread to new sites (metastasis) and survive exposure to chemotherapy (chemoresistance). Additionally, we are working on identifying biomarkers that can help predict outcomes and/or guide therapeutic decisions for patients with osteosarcoma.
We a research-intensive laboratory focussed on improving human health, circadian biology, new treatments for heart disease, and our results are published in high impact journals.
My research program studies the effects of agricultural management practices (tillage and cropping systems) on the nature and dynamics of soil organic matter (SOM).
