David Mutch

Program

Bioinformatics, Human Health & Nutritional Sciences

About the research

Dysfunctional fatty acid metabolism is a hallmark of common chronic diseases such as obesity and type 2 diabetes, as well as an underlying cause of inflammation and insulin resistance. My research investigates the mechanisms that regulate fatty acid metabolism in the body, with a primary focus on adipose (fat) tissue, skeletal muscle, and liver. We are particularly interested to advance understanding of the genetic and dietary regulation of fatty acid desaturases (key enzymes involved in endogenous fatty acid synthesis), and how this modifies cardiometabolic outcomes. Ongoing research in my lab uses cell and rodent models, as well as human clinical trials, to explore how altered omega-3 fatty acid metabolism impacts cellular processes such as adipogenesis, lipogenesis, and lipolysis. 

How the research helps to improve life 

Chronic diseases such as obesity and type 2 diabetes are prevalent in the Canadian population and significantly impact a person's quality of life. While diet and exercise are common approaches used to prevent and treat these diseases, not everyone responds to these interventions in the same way. Omega-3 fatty acids have numerous benefits, including lowering triglycerides and resolving inflammation; however, some people respond differently and show the opposite effects. My research aims to identify the genetic, metabolic and lifestyle factors that underlie these different responses, with the ultimate goal of personalizing interventions to improve an individual's health.