Jim Uniacke | Graduate & Postdoctoral Studies

Jim Uniacke

Portrait of Jim Uniacke


My laboratory investigates how the protein synthesis machinery adapts to environmental stresses such as hypoxia, and how cancer cells exploit the hypoxic protein synthesis machinery for tumor progression.


About my research…

Research in our laboratory will build upon the discovery that cells switch to an alternative protein synthesis machinery during periods of oxygen scarcity (hypoxia). One of our main focuses is on cancer because as human tumors display considerable diversity in their genetic makeup, they share common physiological attributes such as a hypoxic microenvironment that contribute to the malignant phenotype. Therefore, understanding how this alternate mode of protein synthesis, a mechanism scarcely used by normal oxygenated cells, functions and contributes to the expression of the tumor cell phenotype will provide unique opportunities for cancer therapy.